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Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national

So Young Kim1, Hye-Rim Kim2, Chanyang Min3,4

  • 1Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Pediatric Research
|January 11, 2020
PubMed

Insights

Gastroesophageal reflux disease (GERD) and asthma show a two-way link in children. Children with asthma have a higher risk of GERD, and those with GERD are more likely to develop asthma.

Area of Science:

  • Pediatric medicine
  • Gastroenterology
  • Pulmonology

Background:

  • The relationship between asthma and gastroesophageal reflux disease (GERD) in pediatric populations remains unclear.
  • Investigating this connection is crucial for understanding disease development and improving treatment strategies in children.

Purpose of the Study:

  • To investigate the potential bidirectional causal relationship between asthma and GERD in children.
  • To determine if childhood asthma increases the risk of developing GERD and vice versa.

Main Methods:

  • A large-scale cohort study utilizing the Korean Health Insurance Review and Assessment Service-National Sample Cohort (2002-2013).
  • Study I: 86,096 children with asthma were matched with 86,096 controls to assess GERD risk.
  • Study II: 532 children with GERD were matched with 1,064 controls to assess asthma risk. Stratified Cox proportional hazard ratios were analyzed.

Main Results:

  • Children with asthma exhibited a 1.36 times higher hazard ratio (HR) for developing GERD compared to controls (P < 0.001).
  • Children with GERD demonstrated a 1.62-fold higher HR for developing asthma compared to controls (P < 0.001).
  • Consistent findings were observed across subgroup analyses based on age and sex.

Conclusions:

  • Asthma and GERD exhibit a significant bidirectional relationship in children.
  • The findings suggest that these two conditions may influence each other's development in pediatric patients.
  • Further research is warranted to elucidate the underlying mechanisms driving this association.
Abstract

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