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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

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Scaffold strategies for modulating immune microenvironment during bone regeneration.

Jianhua He¹, Guobao Chen¹, Mengying Liu¹

¹Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, PR China; Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing 400044, PR China.

Materials Science & Engineering. C, Materials for Biological Applications

|January 12, 2020

Summary

Bone scaffold design is crucial for successful integration, as physical and chemical properties influence the immune response during bone regeneration. Optimizing these properties and incorporating immunomodulatory agents can enhance implant performance.

Keywords:

Bone regeneration Host response Immune microenvironment Macrophages Osteogenesis Scaffold

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Area of Science:

Biomaterials Science
Tissue Engineering
Immunology

Background:

Bone scaffold integration failure is often linked to unfavorable host immune responses.
Scaffold properties significantly influence cellular behavior and the immune environment during bone regeneration.

Purpose of the Study:

To review recent advances in bone scaffolds focusing on modulating immune responses.
To highlight the role of physical and chemical scaffold properties in manipulating host responses.
To discuss the incorporation of immunomodulatory agents and future directions.

Main Methods:

Review of literature on bone scaffold design and immune response modulation.
Analysis of physical and chemical properties influencing host-scaffold interactions.
Examination of strategies involving bioactive molecules and immunoregulatory cells.

Main Results:

Bone scaffold properties critically dictate the immune microenvironment, impacting bone regeneration.
Tailoring scaffold characteristics can promote favorable immune reactions for enhanced integration.
Incorporation of specific molecules and cells offers a promising approach for immune modulation.

Conclusions:

Strategic design of bone scaffolds is essential for eliciting appropriate immune responses.
Future research should focus on advanced scaffold-based strategies to control the immune microenvironment for improved bone implants.