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Cerebral venous sinus thrombosis as the initial presentation of systemic lupus erythematosus

T Chandra1, J S Tilstra2

  • 1Department of Internal Medicine, University of Connecticut Health Center, Farmington, USA.

Lupus
|January 12, 2020
PubMed

Systemic lupus erythematosus (SLE) is a hypercoagulable state due to a variety of mechanisms. Herein, we discuss the case of a 40-year-old gentleman who presented with cerebral venous sinus thrombosis (CVST) as the first manifestation of underlying SLE. On initial presentation, he did not endorse any other signs and symptoms to suggest the presence of an autoimmune condition. Work-up revealed an absence of antiphospholipid antibodies. Further evaluation uncovered the underlying etiology of the CVST as SLE-induced nephrotic syndrome. The existing literature on CVST suggests that there are only two other biopsy-proven cases of lupus nephritis leading to nephrotic range proteinuria as the etiology for CVST. Given the rarity of this presentation, there are no clearly delineated treatment strategies.

Keywords:
SLEcerebral venous sinus thrombosislupus nephritis

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