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Malignant lymphoma in three horses with ulcerative pharyngitis
R Adams1, M B Calderwood-Mays, L C Peyton
1Department of Surgical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
Journal of the American Veterinary Medical Association
|September 15, 1988
Summary
Malignant lymphoma was diagnosed in three horses with ulcerative pharyngitis unresponsive to treatment. Lymph node biopsies revealed neoplastic lymphocytes disrupting architecture, confirming the diagnosis.
Area of Science:
- Veterinary Pathology
- Equine Medicine
- Oncology
Background:
- Ulcerative pharyngitis in horses can present with non-specific clinical signs.
- Treatment-resistant pharyngeal inflammation necessitates further diagnostic investigation.
Observation:
- Histological examination of pharyngeal lesions showed a mixed inflammatory cell population, including lymphocytes and histiocytes.
- These findings initially suggested chronic inflammation rather than a neoplastic process.
Findings:
- Biopsy specimens from regional lymph nodes revealed neoplastic lymphocytes disrupting the normal lymph node architecture.
- This disruption of lymph node architecture was critical for diagnosing malignant lymphoma.
Implications:
- Highlights the importance of lymph node biopsy in diagnosing obscure equine inflammatory conditions.
- Suggests that malignant lymphoma should be considered in horses with persistent ulcerative pharyngitis.
- Provides histopathological criteria for differentiating chronic inflammation from lymphoma in equine pharyngeal disease.