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Selection from a pool of self-assembling lipid replicators.

Ignacio Colomer1, Arseni Borissov1, Stephen P Fletcher2

  • 1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

Nature Communications
|January 12, 2020
PubMed
Summary
This summary is machine-generated.

Selection emerged in self-reproducing lipid systems. Phase separation and kinetics drove the emergence of a predominant lipid species from competing replicators, offering insights into the origins of life.

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Area of Science:

  • Origin of life studies
  • Chemical evolution
  • Systems chemistry

Background:

  • Replication and compartmentalization are key to life's origins.
  • Autocatalytic systems in compartments may facilitate evolution from non-living matter.

Purpose of the Study:

  • To investigate selection in self-reproducing lipid systems.
  • To understand how a predominant species can emerge from competing replicators.

Main Methods:

  • Studied a system of self-reproducing lipids.
  • Utilized phase separation to enable selective surfactant formation and autocatalytic kinetics.
  • Maintained an out-of-equilibrium population by supplying starting materials.

Main Results:

  • A predominant lipid species emerged from a pool of competitors.
  • Phase separation was essential for selection; no selection occurred in a single-phase system.
  • Selection was driven by a kinetically controlled process based on monomer formation rates.

Conclusions:

  • Kinetics in phase-separated autocatalytic reactions can control populations of out-of-equilibrium replicators.
  • This provides a model for how selection and evolution could arise in early life systems.