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SWAV: a web-based visualization browser for sliding window analysis.

Zhenglin Zhu1, Yawang Wang2,3, Xichuan Zhou4

  • 1School of Life Sciences, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, China. zhuzl@cqu.edu.cn.

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|January 12, 2020
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Summary
This summary is machine-generated.

We developed the Sliding Window Analysis Viewer (SWAV), a web tool for visualizing population genetic data. SWAV integrates, displays, and annotates genomic test statistics, enhancing evolutionary biology research.

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Area of Science:

  • Population genetics
  • Evolutionary biology
  • Bioinformatics

Background:

  • Sliding window analysis is crucial in evolutionary biology.
  • High-throughput sequencing necessitates tools for visualizing population-level genomic data.
  • Existing methods lack dedicated visualization for population genetic statistics.

Purpose of the Study:

  • To develop a web-based application for visualizing population genetic test statistics at the genomic level.
  • To integrate, view, browse, and annotate genomic data using sliding window analysis.
  • To enhance the effectiveness of sliding window analyses through advanced visualization and search functionalities.

Main Methods:

  • Development of a web-based program named Sliding Window Analysis Viewer (SWAV).
  • Integration and visualization of population genetic test statistics.
  • Genome annotation capabilities.
  • Customizable image generation and search functions by sequence alignment, position, or gene name.

Main Results:

  • SWAV enables effective integration, visualization, and annotation of genomic test statistics.
  • The tool facilitates custom statistical image generation and targeted data searching.
  • Demonstrated application on yeast and silkworm resequencing data.

Conclusions:

  • SWAV provides a valuable platform for analyzing and visualizing population genetic data.
  • The tool enhances the utility of sliding window analysis in genomic research.
  • SWAV is accessible online with comprehensive documentation and demos.