Comparison of retinal layer thickness measurements obtained using two different swept-source optical coherence...

Area of Science:

• Ophthalmology
• Medical Imaging

Background:

• Optical coherence tomography (OCT) is crucial for retinal imaging.
• Swept-source OCT offers advanced visualization of retinal layers.
• Accurate segmentation is vital for quantitative retinal analysis.

Purpose of the Study:

• To compare retinal layer thickness measurements between two swept-source OCT wide scan modes.
• To evaluate the reliability of automated and semi-automated segmentation for different retinal layers.

Main Methods:

• Fifty-four healthy eyes underwent OCT imaging using 3D wide and 12 radial wide scan protocols.
• Measurements included full retinal, retinal nerve fiber layer (RNFL), and ganglion cell-inner plexiform layer (GC-IPL) thicknesses.
• Segmentation methods included fully automated and semi-automated correction.

Main Results:

• Intraclass correlation coefficients (ICCs) for full retinal thickness were high (0.958-0.996) for both protocols.
• ICCs for GC-IPL thickness ranged from 0.754-0.918.
• ICCs for RNFL thickness showed significant variability (0.013-0.727).

Conclusions:

• Fully automated segmentation in 3D wide mode provides reliable full retinal thickness measurements.
• The 12 radial wide scan protocol with fully automated segmentation demonstrated segmentation errors for RNFL and GC-IPL.
• Clinical acceptability of RNFL and GC-IPL measurements varies between the two OCT protocols.