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Updated: Dec 31, 2025

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury.

Sripadh Sharma¹, Igal Ifergan², Jonathan E Kurz³

¹Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago.

Annals of Neurology

|January 12, 2020

Summary

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Neurobiology of disease·2017

Immunomodulatory nanoparticles (IMPs) offer a promising new treatment for traumatic brain injury (TBI). These nanoparticles prevent harmful immune cell entry into the brain, preserving function and anatomy after TBI.

Area of Science:

Neuroscience
Immunology
Nanotechnology

Background:

Traumatic brain injury (TBI) lacks effective disease-modifying therapies.
Secondary damage following TBI contributes significantly to poor outcomes.
Targeting specific immune cell infiltration presents a potential therapeutic strategy.

Purpose of the Study:

To evaluate immunomodulatory nanoparticles (IMPs) as a potential therapeutic candidate for TBI.
To investigate whether preventing hematogenous monocyte (hMo) infiltration into the brain post-TBI attenuates secondary damage.
To assess the impact of IMPs on anatomic and neurological function preservation after TBI.

Main Methods:

IMPs, made from FDA-approved materials, were intravenously administered to mice subjected to controlled cortical impact (CCI) and closed head injury (CHI) models.

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Related Experiment Videos

Last Updated: Dec 31, 2025

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Published on: April 6, 2014

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

The study utilized wild-type C57BL/6 mice for experimental TBI induction.

Evaluations included assessments of immune cell infiltration, inflammatory status, electrophysiology, motor behavior, edema, and lesion volume.

Main Results:

IMP treatment led to significant preservation of tissue and neurological function in both CCI and CHI models.
A reduction in immune cell infiltration and mitigated inflammatory status of these cells were observed.
Improvements in visual electrophysiologic function, long-term motor behavior, reduced edema, and smaller lesion volumes were documented.

Conclusions:

IMPs demonstrate potential as a clinically translatable acute intervention for TBI.
The mechanism of action involves ablating specific hematogenous monocytes (hMos).
IMPs promote beneficial anatomic and physiologic preservation and recovery following TBI.