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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Surfactant replacement therapy: from biological basis to current clinical practice
Roland Hentschel1, Kajsa Bohlin2, Anton van Kaam3
1Division of Neonatology and Intensive Care, Department of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany. roland.hentschel@uniklinik-freiburg.de.
Pediatric Research
|January 12, 2020
Summary
This review explores pulmonary surfactant
Area of Science:
- Pulmonary Medicine
- Biochemistry
Background:
- Pulmonary surfactant is crucial for lung function.
- Genetic diseases offer insights into surfactant function.
- Current knowledge covers surfactant physiology and therapy.
Purpose of the Study:
- To review current knowledge on pulmonary surfactant.
- To discuss animal-derived and synthetic surfactant therapy for RDS.
- To highlight future research directions.
Main Methods:
- Literature review of pulmonary surfactant research.
- Analysis of physicochemical properties and functions.
- Evaluation of therapeutic applications and administration techniques.
Main Results:
- Understanding of surfactant components and genetic influences has advanced.
- Animal-derived surfactants are established for RDS therapy.
- New synthetic surfactants show promise but require further definition.
Conclusions:
- Optimizing surfactant therapy requires understanding lung mechanics post-administration.
- Future development focuses on novel synthetic surfactants and administration methods.
- Pulmonary surfactant remains a critical therapeutic agent in neonatology.
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