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Updated: Dec 31, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Ketone bodies, stress response, and redox homeostasis
Pedro Rojas-Morales1, José Pedraza-Chaverri1, Edilia Tapia2
1Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Abstract:
The ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate, as it regulates a broad range of physiological processes at cellular and systemic levels. Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an antioxidant defense program to maintain redox homeostasis in response to environmental and metabolic challenges, such as ischemia. This property of β-hydroxybutyrate might be key for the beneficial effect of calorie restriction on stress response and disease processes.
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