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Updated: Dec 31, 2025
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Novel therapeutic strategies for Alzheimer's disease: Implications from cell-based therapy and nanotherapy
Hossein Derakhshankhah1, Soraya Sajadimajd2, Samira Jafari1
1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which leads to progressive dysfunction of cognition, memory and learning in elderly people. Common therapeutic agents are not only inadequate to suppress the progression of AD pathogenesis but also produce deleterious side effects; hence, development of alternative therapies is required to specifically suppress complications of AD. The current review provides a commentary on conventional as well as novel therapeutic approaches with an emphasis on stem cell and nano-based therapies for improvement and management of AD pathogenesis. According to our overview of the current literature, AD is a multi-factorial disorder with various pathogenic trajectories; hence, a multifunctional strategy to create effective neuroprotective agents is required to treat this disorder.
Insights
Alzheimer's disease (AD) treatments are insufficient and cause side effects. Novel stem cell and nano-based therapies offer promising neuroprotective strategies for managing AD pathogenesis.
Area of Science:
- Neuroscience and Pharmacology
- Biotechnology and Nanomedicine
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting cognition, memory, and learning in the elderly.
- Current therapeutic agents for AD are often inadequate in halting disease progression and can cause adverse side effects.
Purpose of the Study:
- To review conventional and novel therapeutic strategies for Alzheimer's disease.
- To emphasize the potential of stem cell and nano-based therapies in managing AD pathogenesis.
Main Methods:
- Comprehensive literature review of existing and emerging AD treatment approaches.
- Analysis of the efficacy and challenges associated with various therapeutic modalities.
Main Results:
- Conventional therapies show limitations in suppressing AD progression and managing side effects.
- Stem cell and nano-based therapies present promising avenues for neuroprotection and AD management.
- A multifunctional therapeutic strategy is necessary due to the multifactorial nature of AD.
Conclusions:
- There is a critical need for alternative therapies beyond conventional treatments for Alzheimer's disease.
- Stem cell and nano-based approaches warrant further investigation for their neuroprotective potential in AD.
- Future AD treatment strategies should adopt a multifunctional approach to address the complex pathology.
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