Risk assessment of PFASs in drinking water using a probabilistic risk quotient methodology

We evaluated health risks associated with perfluorinated and polyfluorinated alkyl substances (PFASs) found in drinking water applying human risk assessment (HRA) methodology. Using data on worldwide occurrence of PFASs in drinking water and recent guidelines for PFASs in drinking water, we applied four scenarios based on different toxicological threshold values to calculate age-dependent risk quotients (RQ) for different PFASs. The mean concentrations of the most frequently detected compounds (PFOS and PFOA) were highest in North America (99.2 and 30.7 ng L^-1, respectively), and lowest in Asia (PFOS: 3.0 ng L^-1) and Europe (PFOA: 4.87 ng L^-1). Using HRA methodology and maximum reported concentrations, only PFOS and PFOA, examined individually, showed any threat to human health. Specifically, calculations with the average and maximum concentrations of PFOS showed RQ values higher than 0.2 or 1, respectively, for some age groups under specific scenarios. Similarly, using maximum PFOA concentrations, a RQ equal to 0.2 for infants up to 3 months was calculated under scenario 4. Regional differences on RQ values were observed when PFOS concentrations from Europe, North America and Asia were used. Estimation of the human health risk due to mixtures of PFASs using average concentrations showed that the RQ_mix was higher than 0.2 for infants up to 3 months (scenario 3) and infants and children up to 6 years old (scenario 4). More importantly, evaluation of the guideline values set by the EU and the Health Advisory Levels issued by the USEPA resulted (under some scenarios) in RQ values higher than 0.2 for PFOS and PFOA for specific age groups, indicating that further discussion is needed for the monitoring and prioritization of these compounds.