Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

767
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
767

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut microbiota restructured by social isolation: Evidence for sex-specific response patterns.

Brain, behavior, & immunity - health·2026
Same author

The joint anti-hepatocellular carcinoma mechanism of selenium and lenvatinib mediated by Nrf2-ferroptosis axis in M2 tumor associated macrophage.

Free radical biology & medicine·2026
Same author

Enhanced Biocontrol of Root-Knot Nematodes Through Co-Cultivation of <i>Clonostachys rosea</i> and <i>Bacillus velezensis</i>: Proline-Driven Bacterial Fitness and Synergistic Metabolite Production.

Journal of fungi (Basel, Switzerland)·2026
Same author

OsWRI1a coordinates systemic growth responses to nitrogen availability in rice.

Science (New York, N.Y.)·2026
Same author

The Maize ZmbHLH118 Transcription Factor Regulates Vacuolar Nitrate Loading by the NO<sub>3</sub> <sup>-</sup> Transporter ZmCLCa.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

OsSIZ1 regulates rice nitrogen-use efficiency and grain yield by modulating auxin levels.

Journal of integrative plant biology·2026

Related Experiment Video

Updated: Dec 31, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.7K

The Microbiota in Hematologic Malignancies.

Yajing Song1, Bryan Himmel2, Lars Öhrmalm3

  • 1Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, 1 Illini Dr, Peoria, IL, 61605, USA.

Current Treatment Options in Oncology
|January 14, 2020
PubMed
Summary
This summary is machine-generated.

The human microbiota influences hematologic malignancy treatments and patient outcomes. Modulating the gut microbiota may reduce chemotherapy side effects and combat drug-resistant infections in these patients.

Keywords:
Bloodstream infectionHematologic malignanciesLeukemiaMetagenomicsMicrobiota

More Related Videos

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

12.6K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.2K

Related Experiment Videos

Last Updated: Dec 31, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.7K
Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

12.6K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.2K

Area of Science:

  • Oncology
  • Microbiology
  • Immunology

Background:

  • Hematologic malignancies cause significant global mortality and morbidity, particularly in children.
  • Current treatments, while improving survival, cause severe side effects and long-term complications.
  • The human microbiota, predominantly in the gut, plays crucial roles in digestion, immunity, and development.

Purpose of the Study:

  • To explore the implications of human microbiota in hematologic malignancy patients.
  • To investigate the microbiota's influence on hematopoiesis and treatment efficacy.
  • To identify microbiota-based strategies for reducing treatment toxicity and combating resistance.

Main Methods:

  • Review of existing literature on hematologic malignancies and human microbiota.
  • Analysis of the microbiota's role in hematopoiesis and treatment response.
  • Exploration of potential therapeutic interventions targeting the microbiota.

Main Results:

  • Microbiota composition impacts hematopoiesis and the effectiveness of chemotherapy and antibiotics.
  • Microbiota analysis may aid in risk stratification and personalized antimicrobial therapy.
  • Microbiota modulation (e.g., probiotics, fecal transplants) shows promise in mitigating treatment side effects.

Conclusions:

  • The human microbiota is a critical factor in hematologic malignancy patient care.
  • Targeting the microbiota offers a potential non-toxic approach to improve treatment outcomes.
  • Further research into microbiota-host interactions is essential for developing novel therapeutic strategies.