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Incidence of myeloproliferative neoplasms - trends by subgroup and age in a population-based study in Sweden
M Hultcrantz1,2, A Ravn Landtblom3, B Andréasson4
1Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Background:
The reported incidence of Philadelphia-negative myeloproliferative neoplasms (MPNs) differs substantially between previous reports, likely due to true regional differences in incidence and/or variations in the quality and coverage of the cancer registers.
Objective:
We therefore assessed MPN incidence in Sweden during recent years using prospectively collected information captured in Swedish health registers.
Methods:
Patients with MPNs were identified through the Swedish Cancer Register and Swedish Blood Cancer Register between 2000 and 2014. Information on the Swedish population was obtained from the Human Mortality Database. Crude and age-standardized incidence rates of MPNs with 95% confidence intervals (CIs) were calculated.
Results:
A total of 6281 MPN cases were reported to the Swedish Cancer Register and Swedish Blood Cancer Register during 2000-2014. The age-standardized, to the Swedish population in 2000, incidence for all MPNs was 4.45 (95% confidence interval [CI] 4.34-4.56)/100 000 person-years. The age-standardized incidence for polycythemia vera was 1.48 (1.42-1.54), for essential thrombocythemia 1.60 (1.53-1.66) and for primary myelofibrosis 0.52 (0.48-0.56)/100 000 person-years, respectively. The incidence rate of MPNs was substantially higher in the older compared to the younger age groups. The incidence increased during the study period, likely to do better reporting and increasing age of the general population.
Conclusion:
The reported MPN incidences in our study, which were in the higher interval of previously published studies, are likely more accurate compared to previous reports due to the population-based setting and high level of coverage in the Swedish Cancer and Blood Cancer Registers.
Insights
This study reports higher incidence rates for Philadelphia-negative myeloproliferative neoplasms (MPNs) in Sweden. These findings, based on comprehensive national registers, offer a more accurate reflection of MPN occurrence.
Area of Science:
- Hematology
- Oncology
- Epidemiology
Background:
- Reported incidence rates for Philadelphia-negative myeloproliferative neoplasms (MPNs) vary significantly across studies.
- Discrepancies are attributed to regional variations and inconsistencies in cancer registry quality and coverage.
- Accurate incidence data is crucial for understanding disease burden and resource allocation.
Purpose of the Study:
- To assess the incidence of MPNs in Sweden using recent, prospectively collected health register data.
- To establish reliable incidence rates for MPNs and their subtypes within a well-defined population.
- To provide a more accurate epidemiological profile of MPNs in a high-coverage registry setting.
Main Methods:
- Utilized data from the Swedish Cancer Register and Swedish Blood Cancer Register (2000-2014).
- Population data sourced from the Human Mortality Database for accurate rate calculation.
- Calculated crude and age-standardized incidence rates per 100,000 person-years, including 95% confidence intervals.
Main Results:
- Identified 6,281 MPN cases between 2000 and 2014.
- The overall age-standardized incidence for all MPNs was 4.45/100,000 person-years.
- Specific incidences: Polycythemia vera (1.48), Essential thrombocythemia (1.60), and Primary myelofibrosis (0.52) per 100,000 person-years.
- Incidence rates were higher in older age groups and showed an increasing trend over the study period, potentially due to improved reporting and an aging population.
Conclusions:
- The study reports MPN incidence rates at the higher end of previously published estimates.
- The population-based design and high coverage of Swedish registers suggest these findings are more accurate.
- These results provide a robust epidemiological baseline for Philadelphia-negative MPNs.
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