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Altered gentamicin disposition in a child with a cavernous hemangioma
J B Gillespie1, S B Mallory, G L Kearns
1Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
Journal of the American Academy of Dermatology
|November 1, 1988
Abstract:
Physiologic third spacing can cause an increase in the volume of distribution of certain drugs, such as aminoglycosides, which results in a decrease in the serum concentration. The case reported here, that of a child with a large cavernous hemangioma, demonstrated this phenomenon. To obtain adequate serum and tissue concentrations, alteration of antimicrobial dosing may be needed in similar cases.