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Erythrocyte deformability in children with autism spectrum disorder: correlation with clinical features

T Jasenovec1, D Radosinska, H Celusakova

  • 1Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovak Republic. jana.radosinska@fmed.uniba.sk.

Physiological Research
|January 14, 2020
PubMed

Insights

Erythrocyte deformability is reduced in children with autism spectrum disorder (ASD), correlating with repetitive behaviors. This finding suggests altered red blood cells may contribute to ASD pathogenesis and symptoms.

Area of Science:

  • Biomedical science
  • Hematology
  • Neuroscience

Background:

  • Erythrocyte biomechanical properties, particularly deformability, are vital for microcirculation and tissue perfusion.
  • Compromised erythrocyte function is implicated in various diseases, including neurological disorders.
  • Existing data suggest alterations in erythrocytes within autism spectrum disorder (ASD).

Purpose of the Study:

  • To investigate erythrocyte deformability in children diagnosed with ASD.
  • To correlate erythrocyte deformability with specific clinical symptoms of ASD.

Main Methods:

  • Erythrocyte deformability was assessed in 54 children with ASD.
  • Correlations were analyzed between erythrocyte deformability metrics and scores from the Autism Diagnostic Interview-Revised (ADI-R), focusing on behavioral domains.

Main Results:

  • A significant negative correlation was observed between erythrocyte deformability and the 'C' domain scores of the ADI-R, which assesses restrictive, repetitive, and stereotyped behaviors.
  • This correlation was primarily driven by subdomains C1 and C2, indicating a link between reduced erythrocyte flexibility and specific behavioral patterns in ASD.
  • No significant correlation was found with subdomains C3 and C4.

Conclusions:

  • Abnormalities in erythrocyte deformability appear to be associated with the pathomechanisms of ASD.
  • Reduced erythrocyte deformability may contribute to the clinical manifestation of ASD symptoms, particularly repetitive behaviors.
  • Further research is warranted to explore erythrocyte deformability as a potential prognostic biomarker for ASD.

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