Related Experiment Video
Updated: Dec 31, 2025
Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice
Published on: August 20, 2016
Sex-related differences in locomotion and climbing of C57Bl/6NTac mice in a novel environment
V Borbélyová1, K Janišová, J Mysliveček
1Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic. Department of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic. vladimir.riljak@lf1.cuni.cz.
Abstract:
Laboratory mice in standard laboratory cages, besides horizontal and vertical locomotor activity, spontaneously display cage-bar related activities such as cage-grid climbing. Although, grid-climbing activity is one of the major components of spontaneous home-cage behavior of mice, its exact role is not fully understood. This study aimed to describe the sex-differences in coping with novelty and in spontaneous behavior of laboratory mice concerning the cage-climbing activity in an observer-independent open field test. Adult mice of both sexes (C57Bl/6NTac) underwent behavioral testing in LABORAS system. Female mice travelled significantly longer distance (by 30 %, p<0.05) and showed higher grid-climbing activity (by 50 %, p<0.05) than males. Based on our results, the grid-climbing is a sex-dependent activity of mice, however, its exact role remains to be elucidated.
