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Factors adversely influencing neurodevelopment.

T C Theoharides1,2,3,3, M Kavalioti4, R Martinotti5

  • 1Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston. MA, USA.

Journal of Biological Regulators and Homeostatic Agents
|January 14, 2020
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Summary

Environmental factors and inflammatory conditions can impact child neurodevelopment. Early identification and intervention, potentially using natural flavonoids, are crucial for beneficial outcomes.

Keywords:
autismbrainflavonoidsinflammationlearningmast cellsneurodevelopment

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Area of Science:

  • Pediatric Neurodevelopmental Science
  • Environmental Health
  • Immunology

Background:

  • Extensive research exists on neurodevelopmental impacts of abuse, anoxia, nutrition, and prematurity.
  • Less focus has been placed on innate and environmental factors affecting child learning and neurodevelopment.
  • Inflammatory conditions like chronic inflammatory response syndrome (CIRS) and Mast cell activation syndrome (MCAS) are implicated.

Discussion:

  • Environmental toxins such as heavy metals, herbicides, and polyvinyl chlorides (PVCs) can disrupt neurodevelopment.
  • Infectious agents including viral infections and Lyme disease-associated pathogens contribute to neurodevelopmental challenges.
  • The interplay between environmental exposures and inflammatory responses requires further investigation.

Key Insights:

  • Early identification of environmental and inflammatory factors is critical for preventing adverse neurodevelopmental outcomes.
  • Conditions like CIRS and MCAS represent significant, under-recognized influences on pediatric neurodevelopment.
  • Natural flavonoids show potential as therapeutic agents for mitigating negative neurodevelopmental effects.

Outlook:

  • Further research is needed to elucidate the mechanisms by which environmental factors and inflammation impact neurodevelopment.
  • Developing targeted interventions for children exposed to these risk factors is a priority.
  • Investigating the efficacy of natural compounds like flavonoids in clinical settings is warranted.