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Related Experiment Video

Updated: Dec 31, 2025

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Total Microfluidic chip for Multiplexed diagnostics (ToMMx).

Mehmet O Ozen1, Kaushik Sridhar2, Mehmet Giray Ogut2

  • 1Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, School of Medicine Stanford University Palo Alto, CA, 94304, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Biosensors & Bioelectronics
|January 14, 2020
PubMed
Summary

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This summary is machine-generated.

A new disposable microfluidic biosensor (ToMMx) offers rapid, sensitive, and portable multiplexed sensing for clinical diagnostics. This user-friendly platform significantly reduces assay time and cost, making it ideal for point-of-care applications.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Current clinical diagnostic platforms are often multi-step, time-consuming, expensive, and require bulky equipment, limiting their use in resource-limited or point-of-care settings.
  • Existing miniaturized diagnostic platforms often lack batch fabrication capabilities and rely on external components like syringe pumps.

Purpose of the Study:

  • To develop and clinically test a disposable, multiplexed sensing microfluidic device (ToMMx) for portable, high-throughput, and user-friendly biosensing.
  • To evaluate the performance of the ToMMx platform in detecting biomarkers in clinical samples, comparing it to established methods.

Main Methods:

  • Development of a disposable microfluidic sensing device (ToMMx) using inexpensive plastic materials, designed for manual operation without electricity.
Keywords:
Cardiovascular biomarkersMicrofluidicsMultiplexed sensingOn-chip manual biosensing

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  • Clinical validation using a cohort of 50 samples from patients with cardiovascular diseases and healthy controls.
  • Side-by-side comparison with commercial ELISA kits to assess assay time, sensitivity, and quantification.

    • Main Results:

    • The ToMMx platform demonstrated rapid, quantifiable results with high sensitivity (as low as 5.29 pg/mL) from a small sample volume (4 μL).
    • Assay time was reduced 15-fold compared to commercial ELISA kits (20 minutes vs. 5 hours).
    • The platform proved effective in a small cohort of clinical samples for cardiovascular disease detection.

    Conclusions:

    • The ToMMx microfluidic platform is a portable, user-friendly, and cost-effective solution for multiplexed biosensing.
    • This technology significantly reduces assay time and complexity, showing great potential for point-of-care diagnostics and disease monitoring.
    • The disposable and manually operated nature of ToMMx makes it suitable for resource-limited settings and broad clinical applications.