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At last - linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility

Marsha Wills-Karp

    The Journal of Clinical Investigation
    |January 14, 2020
    PubMed
    Summary

    Genetic variants in orosomucoid-like protein 3 (ORMDL3) are linked to childhood asthma. This study finds lower sphingolipids in children with asthma and specific ORMDL3 risk genotypes, suggesting a new therapeutic target.

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