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Von Meyenburg complex clinically presenting as metastatic liver nodule: A rare finding in an elderly male
Nadia Shirazi1, Neena V Chauhan1, Smita Chandra1
1Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.
Abstract:
Von Meyenburg complex is a benign biliary hamartoma observed in approximately 3% of the autopsies conducted. These hamartomas are small, multiple and can be seen anywhere in the liver. There is usually no abnormality in liver function tests, and the patient is mostly asymptomatic. They serve as a diagnostic dilemma, particularly during metastatic workup in suspected cancer patients. Imaging studies are usually noncontributory, and biopsy is necessary for a definite diagnosis. We present here a middle-aged North Indian male who underwent liver biopsy to rule out metastasis.
Insights
Von Meyenburg complexes are benign liver tumors found in about 3% of autopsies. Diagnosis can be challenging, often requiring a liver biopsy to rule out cancer metastasis.
Area of Science:
- Hepatology
- Pathology
- Radiology
Background:
- Von Meyenburg complexes, also known as biliary hamartomas, are rare benign liver malformations.
- They are typically found incidentally during autopsies or liver imaging.
- Often asymptomatic, they present a diagnostic challenge, especially in oncology settings.
Observation:
- The case involves a middle-aged North Indian male presenting with a diagnostic dilemma during a metastatic workup.
- Multiple small lesions were observed, consistent with the typical presentation of Von Meyenburg complexes.
- Standard liver function tests showed no significant abnormalities.
Findings:
- Imaging studies were inconclusive for a definitive diagnosis.
- A liver biopsy was performed to differentiate the lesions from metastatic disease.
- Histopathological examination confirmed the diagnosis of Von Meyenburg complex.
Implications:
- This case highlights the importance of considering benign biliary hamartomas in the differential diagnosis of liver lesions.
- Accurate diagnosis is crucial to avoid unnecessary aggressive treatment for presumed malignancy.
- Awareness among clinicians and radiologists is key for appropriate patient management.
