Stromal Cell-derived Factor-1 and CXC Chemokine Receptor Type-4 are Associated with Cardiovascular Disease in
Seyed Hossein Mousavi1, Banafsheh Dormanesh2, Shahrzad Shahidi3,4
1Department of Cardiology, AJA University of Medical Sciences, Tehran, Iran.
Insights
Higher levels of Stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor type-4 (CXCR4) are linked to cardiovascular disease (CVD) in hemodialysis patients. These factors also correlate with traditional and uremia-related CVD risk factors.
Area of Science:
- Nephrology
- Cardiology
- Molecular Biology
Background:
- Cardiovascular disease (CVD) is the leading cause of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD).
- Stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor type-4 (CXCR4) are implicated in the pathogenesis of CVD.
Purpose of the Study:
- To investigate the association between SDF-1 and CXCR4 levels and CVD in patients on hemodialysis.
- To explore the relationship between SDF-1, CXCR4, and traditional/uremia-related CVD risk factors in this population.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR) were used to measure serum and mRNA levels of SDF-1 and CXCR4.
- Sixty HD patients and 29 healthy controls were included; CVD history was recorded.
Main Results:
- Patients on HD exhibited significantly higher serum and mRNA levels of SDF-1 and CXCR4 compared to controls.
- Elevated SDF-1 and CXCR4 levels were observed in HD patients with a history of CVD.
- SDF-1 and CXCR4 levels positively correlated with blood urea nitrogen, parathyroid hormone, and high-sensitivity C-reactive protein, and inversely with hemoglobin.
Conclusions:
- Increased serum and mRNA expression of SDF-1 and CXCR4 are associated with CVD in hemodialysis patients.
- SDF-1 and CXCR4 are linked to several traditional and uremia-related cardiovascular risk factors in patients undergoing HD.
Background:
Cardiovascular disease (CVD) is the most common cause of death among patients with end-stage renal disease especially whom under hemodialysis (HD). Stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor type-4 (CXCR4) could contribute to CVD. The main aim of this study was to evaluate the association between SDF-1 and CXCR4 with CVD and its related risk factors in patients under HD.
Methods:
Sixty patients under HD and 29 healthy subjects were recruited in the study. The serum levels and relative messenger RNA (mRNA) expressions of SDF-1 and CXCR4 were measured using enzyme-linked immunosorbent assay and real-time polymerase chain reaction in patients and controls, respectively. CVD history of the patients was obtained.
Results:
Twenty patients (33.3%) had a history of CVD. The mean levels of serum and relative mRNA expressions of SDF-1 and CXCR4 were higher in patients than controls and also in patients with a history of CVD than patients without it. The serum levels and relative expressions of SDF-1 and CXCR4 were positively correlated with blood urea nitrogen, parathyroid hormone, and high-sensitivity C-reactive protein and inversely correlated with hemoglobin. The history of CVD was the independent predictor of serum levels of SDF-1 and CXCR4 and also relative mRNA expression of CXCR4.
Conclusions:
The higher levels of serum and relative mRNA expressions of SDF-1 and CXCR4 were associated with CVD in patients under HD. Furthermore, SDF-1 and CXCR4 were associated with several traditional and uremia-related CVD risk factors in such patients.
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