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CMTTdb: the cancer molecular targeted therapy database
Xue Bai1,2,3, Xiaobo Yang1,2, Liangcai Wu1,2,4,5
1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China.
Annals of Translational Medicine
|January 14, 2020
Summary
The Cancer Molecular Targeted Therapy database (CMTTdb) consolidates data from 1,088 clinical trials on targeted anticancer agents. This resource aids oncologists in optimizing cancer treatment strategies.
Area of Science:
- Oncology
- Pharmacology
- Bioinformatics
Background:
- Molecular targeted therapy represents a significant advancement in cancer treatment.
- The rapid expansion of clinical trials necessitates organized data integration for clinical guidance.
Purpose of the Study:
- To develop a comprehensive database (CMTTdb) for molecular targeted therapy clinical trial information.
- To facilitate the retrieval and utilization of data on targeted agents, their mechanisms, and clinical applications.
Main Methods:
- Construction of the Cancer Molecular Targeted Therapy database (CMTTdb).
- Inclusion of data on randomized clinical trials (RCTs), targeted agents, biomarkers, and cancer subtypes.
- Focus on clinical trial design, treatment modalities, efficacy, and adverse events.
Main Results:
- CMTTdb contains data from 1,088 clinical trials, covering 165 agents and 80 targets across 15 cancer types.
- The database includes detailed information on molecular and histological subtypes.
- A user-friendly web interface provides easy access to the data at http://www.biosino.org/CMTTdb.
Conclusions:
- CMTTdb serves as a valuable resource for accessing information on novel targeted cancer agents.
- The database can assist oncologists in optimizing cancer therapy strategies.
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