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Safety and efficacy of interferon γ in friedreich's ataxia

Marinela Vavla1, Maria Grazia D'Angelo1, Filippo Arrigoni1

  • 1IRCCS E. Medea Scientific Institute, Conegliano, (TV), Italy.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 14, 2020
PubMed
Abstract

No abstract available in PubMed .

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

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