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Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
Published on: September 22, 2023
Regulation of immune-driven pathogenesis in Parkinson's disease by gut microbiota
Wenxia Zheng1, Rongni He2, Zhenxing Yan1
1Department of Neurology, Zhujiang Hospital, Southern Medical University, 253 Gongye Avenue Middle, Guangzhou, Guangzhou 510282, China.
Abstract:
Parkinson's disease (PD) is one of the most significant medical and social burdens of our time. The prevalence of PD increases with age and the number of individuals diagnosed with PD is expected to double from 6.9 million in 2015 to 14.2 million in 2040. To date, no drugs can stop the ongoing neurodegeneration caused by PD due to its unclear and complex pathogenic mechanisms. It has been wildly recognized that both gut microbiota and neuro-immunity are involved in the pathology of PD. In this review, we intend to provide a comprehensive overview of current knowledge on how gut microbiota involved in immune-driven pathogenesis of PD, and its potential as a new target of dietary and/or therapeutic interventions for PD.
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