Related Experiment Video
Updated: Dec 31, 2025
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Relationship between polymorphisms of CXCL3 gene and preeclampsia
Jie Ren1, Yanping Zhang1, Jin Jia1
1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of Education, Chengdu, Sichuan, PR China.
Insights
The rs370655 polymorphism in the CXCL3 gene is not associated with preeclampsia risk. Further research into other single nucleotide polymorphisms (SNPs) within CXCL3 may offer insights into predicting preeclampsia.
Area of Science:
- Genetics
- Obstetrics
- Molecular Biology
Background:
- Preeclampsia (PE) is a major global cause of maternal and perinatal mortality with unknown pathogenesis.
- PE is increasingly understood as a multifactorial disorder involving genetic components.
- Previous research identified abnormal CXCL3 expression in severe preeclampsia.
Purpose of the Study:
- To investigate the association between CXCL3 gene polymorphisms and preeclampsia susceptibility.
- To analyze the role of the rs370655 variant in preeclampsia risk among women in western China.
Main Methods:
- A case-control study involving 481 pregnant women (83 early-onset severe PE, 114 late-onset severe PE, 41 mild PE, 243 controls).
- Genotyping of the rs370655 variant in the CXCL3 gene using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Main Results:
- No significant association was found between the rs370655 AA genotype and reduced preeclampsia risk compared to other genotypes (AG vs. AA: OR=0.82, 95%CI=0.54-1.26; GG vs. AA: OR=0.95, 95%CI=0.56-1.61).
- Subgroup analyses for mild, early-onset severe, and late-onset severe preeclampsia also revealed no significant genotype-based differences.
Conclusions:
- The rs370655 polymorphism in the CXCL3 gene does not appear to be a risk factor for preeclampsia.
- Investigating other single nucleotide polymorphisms (SNPs) in the CXCL3 gene may be crucial for understanding and predicting preeclampsia.
Background:
Preeclampsia (PE), a pregnancy-specific disease, is a main cause of maternal and perinatal mortality in the world, the exact pathogenesis of which is still unknown. Recent studies have found it is a disorder caused by multiple factors and genes. Previously, we found a significantly abnormal expression of CXCL3 in plasma and placenta of severe preeclampsia. Here, we intend to explore the association of polymorphisms in CXCL3 gene with preeclampsia susceptibility in women from western China.
Methods:
Four hundred eighty-one pregnant women were involved in this case-control study, including 83 early-onset severe preeclampsia cases, 114 late-onset severe preeclampsia cases, 41 mild preeclampsia cases and 243 normal pregnancies. The rs370655 variant in CXCL3 was detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results:
No significantly reduced risk of preeclampsia is observed in the rs370655 AA genotype compared with other genotypes (AG versus AA: OR = .82, 95%CI = .54-1.26; GG versus AA: OR = .95, 95%CI = .56-1.61). After subgroup analysis, there are still no significant differences among various genotypes in the mild preeclampsia, early-onset severe preeclampsia and late-onset sever preeclampsia.
Conclusion:
Our study suggests that rs370655 polymorphism in CXCL3 gene may be not the risk factor of preeclampsia, exploring other consequential SNPs in CXCL3 gene may help to predict the preeclampsia.
More Related Videos
05:30Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
Published on: November 8, 2024
12:02Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
Related Concept Videos
01:58Cell Specific Gene Expression
01:09Epistasis Analysis
01:28Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...