Salivary Biomarker Interleukin-8 Levels in Naswar Users and Non-users

Area of Science:

• Oral oncology
• Biomarker research
• Diagnostic aids

Background:

• Salivary biomarkers show promise for early oral cancer detection.
• Naswar use is a significant risk factor for oral potentially malignant disorders.

Purpose of the Study:

• To compare salivary Interleukin-8 (IL-8) levels between naswar users and non-users.
• To investigate IL-8 as a potential salivary biomarker in oral cancer risk assessment.

Main Methods:

• Cross-sectional comparative study involving 60 participants (naswar users and non-users).
• Un-stimulated saliva samples analyzed using enzyme-linked immunosorbent assay (ELISA).
• Statistical analysis performed using independent t-test in SPSS.

Main Results:

• A statistically significant difference in salivary IL-8 levels was observed (p <0.001).
• Naswar users exhibited markedly elevated IL-8 levels (173.48 ±46.52 pg/ml) compared to non-users (33.39 ±22.44 pg/ml).

Conclusions:

• Elevated salivary IL-8 levels are strongly associated with naswar usage.
• Salivary IL-8 may serve as a valuable biomarker for identifying individuals at higher risk of oral cancer.