Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.1K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.1K
Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

4.2K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
4.2K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

4.0K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
4.0K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

624
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
624
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

657
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
657
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

6.3K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adult Chronic Pancreatitis Working Group: Goals, Accomplishments and the Path Ahead. A Report From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Pancreas·2026
Same author

Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study.

Diabetes care·2026
Same author

Whole Metagenomic Profiling Identifies a Gut Microbial Signature for Chronic Pancreatitis via Machine Learning.

Pancreas·2026
Same author

Complications of Pancreatitis-Knowledge Gaps and Research Opportunities: A Workshop Summary.

Pancreas·2026
Same author

Digital cognitive-behavioral therapy for pain management in individuals with recurrent acute and chronic pancreatitis (IMPACT-2): study protocol for a hybrid effectiveness-implementation trial.

Trials·2026
Same author

Comprehensive Assessment of Direct and Passive Smoking Across the Pancreatitis Spectrum.

Pancreas·2026

Related Experiment Video

Updated: Dec 31, 2025

Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices
10:49

Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices

Published on: April 13, 2021

4.7K

Lipocalin-2 expression and function in pancreatic diseases.

Kristyn Gumpper1, Andrew William Dangel1, Valentina Pita-Grisanti1

  • 1Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA; The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|January 15, 2020
PubMed
Summary

Lipocalin-2 (LCN2) shows potential as a biomarker for pancreatic cancer and pancreatitis, but its role in these diseases and type 2 diabetes remains unclear. Further research is needed to clarify LCN2

Keywords:
Lipocalin-2Neutrophil gelatinase-associated lipocalinObesityPancreatic cancerPancreatitis

More Related Videos

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
05:51

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices

Published on: April 12, 2021

4.5K
Evaluating Autophagy Levels in Two Different Pancreatic Cell Models Using LC3 Immunofluorescence
08:07

Evaluating Autophagy Levels in Two Different Pancreatic Cell Models Using LC3 Immunofluorescence

Published on: April 28, 2023

1.9K

Related Experiment Videos

Last Updated: Dec 31, 2025

Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices
10:49

Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices

Published on: April 13, 2021

4.7K
Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
05:51

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices

Published on: April 12, 2021

4.5K
Evaluating Autophagy Levels in Two Different Pancreatic Cell Models Using LC3 Immunofluorescence
08:07

Evaluating Autophagy Levels in Two Different Pancreatic Cell Models Using LC3 Immunofluorescence

Published on: April 28, 2023

1.9K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Lipocalin-2 (LCN2) is a secreted protein implicated in various diseases.
  • LCN2 is an adipokine, upregulated in obesity, and linked to pancreatic disorders.
  • Expression levels and functions of LCN2 in pancreatic diseases are not fully understood.

Purpose of the Study:

  • To review and clarify the role of Lipocalin-2 (LCN2) in pancreatic diseases.
  • To highlight discrepancies in current research regarding LCN2's function.
  • To promote the development of novel diagnostic and therapeutic strategies for pancreatic diseases.

Main Methods:

  • Literature review of studies on LCN2 in pancreatic cancer, pancreatitis, and diabetes mellitus.
  • Analysis of LCN2 expression levels in various biological specimens.
  • Synthesis of existing research to identify contradictions and knowledge gaps.

Main Results:

  • LCN2 is a potential biomarker for pancreatic cancer and pancreatitis, with elevated levels correlating with disease presence.
  • LCN2 is upregulated in obesity and associated with pancreatic disease development.
  • The precise role of LCN2 in type 2 diabetes mellitus requires further investigation.

Conclusions:

  • LCN2 holds promise as a diagnostic and therapeutic target for pancreatic diseases.
  • Contradictory findings necessitate further research to elucidate LCN2's exact role.
  • Clarifying LCN2's function can lead to improved management of pancreatic disorders.