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Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study
Atsushi Hozawa1,2, Kozo Tanno3,4, Naoki Nakaya1,2,5
1Tohoku Medical Megabank Organization, Tohoku University.
Journal of Epidemiology
|January 15, 2020
Summary
This large cohort study examines the long-term health impacts of the Great East Japan Earthquake on disaster survivors. Findings highlight psychological distress linked to disaster exposure, informing personalized health strategies.
Area of Science:
- Environmental Health
- Epidemiology
- Genetics
Background:
- Community-based cohort study established post-Great East Japan Earthquake.
- Focuses on long-term health impacts and gene-environment interactions.
- Investigates major disease incidence, including cancer and cardiovascular diseases.
Purpose of the Study:
- Assess the long-term health consequences of the Great East Japan Earthquake on disaster victims.
- Examine gene-environment interactions influencing disease incidence.
- Establish personalized prevention strategies using omics data.
Main Methods:
- Recruited participants aged 20+ in Miyagi/Iwate Prefectures.
- Collected lifestyle, disaster impact, and biospecimen data (Type 1 & 2 surveys).
- Included detailed measurements like carotid echography and bone density; obtained consent for genome data sharing.
Main Results:
- 87,865 participants consented; 70% participation rate at check-up sites.
- Type 1 survey participants reported more psychological distress than Type 2.
- Women and coastal residents showed higher psychological distress.
Conclusions:
- The cohort provides a large dataset with disaster, genome, and metabolome information.
- Detailed measurements aid in understanding long-term disaster effects.
- Enables personalized prevention strategies based on omics data and disaster exposure.
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