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Updated: Dec 31, 2025
08:59
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
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Microphysiological systems for ADME-related applications: current status and recommendations for system development
Stephen Fowler1, Wen Li Kelly Chen2, David B Duignan3
1Pharma Research and Early Development, F.Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH4070, Basel, Switzerland.
Lab on a Chip
|January 15, 2020
Summary
Microphysiological systems (MPS) show promise for drug development by modeling human absorption, distribution, metabolism, and excretion (ADME). Interconnected MPS platforms are key for studying organ interactions and reducing animal testing.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Drug Development
Background:
- Significant advancements in microphysiological systems (MPS) for ADME applications over the past decade.
- Proof-of-concept and characterization studies demonstrate scalability and applicability in drug discovery.
Purpose of the Study:
- Review progress in specific tissue MPS development.
- Outline desired functionalities for pharmaceutical industry adoption.
- Highlight the potential of inter-linked MPS for PK/efficacy and PK/toxicity studies.
Main Methods:
- Review of academic and industrial research on MPS.
- Analysis of functional requirements for practical pharmaceutical use.
- Discussion of single-organ vs. inter-linked MPS models.
Main Results:
- Single-organ MPS are valuable for tissue-specific functions.
- Inter-linked MPS are essential for modeling dynamic organ crosstalk.
- MPS platforms show potential to reduce animal model reliance.
Conclusions:
- MPS are advancing for ADME applications in drug development.
- Inter-connected MPS are crucial for comprehensive physiological modeling.
- Successful MPS implementation may decrease drug development risks and costs.
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