Acid-base-governed deep eutectic solvent-based microextraction combined with magnetic solid-phase extraction for...

Area of Science:

• Analytical Chemistry
• Environmental Science
• Green Chemistry

Background:

• Phenolic compounds like bisphenol-A are common environmental contaminants.
• Existing analytical methods may lack sensitivity or require harsh chemicals.
• Development of eco-friendly and efficient extraction techniques is crucial.

Purpose of the Study:

• To develop a sensitive and green method for determining four phenolic compounds.
• To utilize deep eutectic solvents (DESs) for enhanced extraction efficiency.
• To apply the method for analyzing phenolic compounds in beverage samples.

Main Methods:

• Magnetic solid-phase extraction using Mg(II)-Al(III) layered double hydroxide-coated magnetic nanoparticles for sample purification.
• Green deep eutectic solvents (DESs) prepared from medium-chain fatty acids (C8-C12) and D,L-menthol.
• Acid-base induced liquid-liquid microextraction for efficient analyte recovery.

Main Results:

• The method achieved low limits of detection (6-11 ng L⁻¹).
• Good linearity (0.05-500 μg L⁻¹) and high enrichment factors (86-91) were obtained.
• Successful determination of four phenolic compounds in beverage samples with recoveries from 84.4% to 101.3%.

Conclusions:

• The developed method is sensitive, efficient, and environmentally friendly.
• Green DESs combined with acid-base induction offer a promising approach for phenolic compound analysis.
• This technique is suitable for routine analysis of contaminants in food and environmental samples.