Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.3K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.2K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
2.2K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

3.0K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Children born SGA receiving growth hormone have similarly impaired glucose-insulin metabolism as children with obesity.

The Journal of clinical endocrinology and metabolism·2026
Same author

The CrescNet Registry Achondroplasia Module: Real-World Demographic Data and Clinical Outcomes in Untreated and Vosoritide-Treated Individuals.

Hormone research in paediatrics·2026
Same author

A prospective cohort analysis from Germany shows transition into adulthood is an underestimated vulnerable period for children with overweight/obesity.

Communications medicine·2025
Same author

Uniparental disomy leads to a novel cause of MC2R-related familial glucocorticoid deficiency type 1.

European journal of endocrinology·2025
Same author

From Childhood to Adolescence: Long-Term Trends in Severe Obesity in German Youth (2002-2023).

Obesity facts·2025
Same author

Severity of Congenital Heart Defects Affects Long-Term Somatic Development.

Pediatric cardiology·2025

Related Experiment Video

Updated: Dec 31, 2025

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

14.0K

GH and IGF-1 Replacement in Children.

Roland Pfäffle1, Wieland Kiess2

  • 1Department of Pediatric Endocrinology, University Children's Hospital Leipzig, Leipzig, Germany. Roland.Pfaeffle@medizin.uni-leipzig.de.

Handbook of Experimental Pharmacology
|January 15, 2020
PubMed
Summary

Recombinant human growth hormone (rhGH) and IGF-1 treatments for short stature show short-term benefits but long-term height gain is debated. Long-term safety requires further study, especially with new weekly preparations.

Keywords:
Growth hormoneGrowth hormone deficiencyIdiopathic short statureInsulin-like growth factor ILong-acting growth hormoneNoonan syndromePrader-Willi syndromeShort statureSmall for gestational ageTurner syndrome

More Related Videos

Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

3.4K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.6K

Related Experiment Videos

Last Updated: Dec 31, 2025

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

14.0K
Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

3.4K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.6K

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Pharmacology

Background:

  • Recombinant human growth hormone (rhGH) and IGF-1 have been used for over 30 years to treat short stature.
  • Their use extends beyond GH deficiency to various disorders, impacting growth physiology understanding.
  • Long-term safety data is crucial given the therapy's widespread application.

Purpose of the Study:

  • To review the efficacy and safety of rhGH and IGF-1 treatments for short stature.
  • To analyze growth responses and long-term height outcomes in treated children.
  • To discuss the evolving risk-benefit ratio and new therapeutic developments.

Main Methods:

  • Analysis of clinical studies on rhGH and IGF-1 therapy outcomes.
  • Review of published long-term safety data for rhGH treatment.
  • Evaluation of newer long-acting rhGH preparations.

Main Results:

  • Significant short-term growth responses are observed in most patients.
  • Long-term height gain remains controversial for certain growth disorders.
  • Emerging safety data raises questions about universal applicability across patient groups.

Conclusions:

  • While rhGH and IGF-1 offer short-term benefits, long-term efficacy requires further investigation.
  • Ongoing safety evaluations are essential, particularly for diverse patient populations.
  • New weekly rhGH formulations show promise but require long-term safety and adherence data.