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Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells

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Published on: January 18, 2019

Coinfection, Altered Vector Infectivity, and Antibody-Dependent Enhancement: The Dengue-Zika Interplay.

Omomayowa Olawoyin¹, Christopher Kribs²

¹Department of Mathematics, University of Texas at Arlington, 411 South Nedderman Drive, Box 19408, Arlington, TX, 76019, USA. omomayowa.olawoyin@mavs.uta.edu.

Bulletin of Mathematical Biology

|January 15, 2020

Summary

Dengue and Zika coinfection can alter disease spread, with antibody-dependent enhancement (ADE) significantly impacting persistence. Dengue can facilitate Zika spread, but high Zika prevalence may hinder dengue establishment.

Keywords:

Copersistence Dengue Invasion reproductive number Zika

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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Area of Science:

Epidemiology
Mathematical Modeling
Infectious Diseases

Background:

Cocirculation of dengue and Zika viruses is increasing globally.
Limited understanding exists regarding the epidemiological impact of dengue and Zika coinfection.

Purpose of the Study:

To investigate the effect of dengue and Zika coinfection on the spread of both pathogens.
To model the influence of altered mosquito infectivity and antibody-dependent enhancement (ADE) on disease dynamics.

Main Methods:

Development of a deterministic dengue and Zika coinfection model.
Incorporation of altered mosquito infectivity due to coinfection.
Inclusion of antibody-dependent enhancement (ADE) within the human population.
Derivation and interpretation of basic reproductive and invasion reproductive numbers for both pathogens.

Main Results:

Identified threshold conditions where one disease facilitates the spread of the other.
Demonstrated that ADE has a greater impact on disease persistence than altered vector infectivity.
Showcased that endemic dengue can facilitate Zika spread.

Conclusions:

Antibody-dependent enhancement (ADE) plays a critical role in dengue and Zika coinfection dynamics.
The endemic presence of dengue can promote Zika virus transmission.
High Zika prevalence may potentially limit the establishment of dengue.