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Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

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Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

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Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Updated: Dec 31, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Hematological malignancies in connective tissue diseases.

H A Noureldine1, W Nour-Eldine1, M H Hodroj2

  • 1Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.

Lupus
|January 15, 2020
PubMed
Summary

Chronic inflammation promotes tumors, and autoimmune diseases increase cancer risk. Understanding these links is crucial for treating autoimmune conditions and managing cancer risk effectively.

Keywords:
Hematological malignanciesSjögren's syndromeinflammationrheumatoid arthritissystemic lupus erythematosussystemic sclerosis

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Area of Science:

  • Immunology
  • Oncology
  • Rheumatology

Background:

  • Chronic inflammation plays a significant role in tumor development.
  • Immune suppression is linked to an increased risk of developing tumors.
  • Autoimmune diseases, characterized by immune dysregulation, create conditions conducive to tumor growth.

Purpose of the Study:

  • To review the associations between malignancies and specific autoimmune diseases.
  • To discuss the underlying mechanisms linking autoimmune disorders and cancer.
  • To highlight the importance of considering cancer risk in autoimmune disease management.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of existing research on autoimmune diseases and cancer.
  • Synthesis of information on pathogenic mechanisms.

Main Results:

  • Specific autoimmune diseases like lupus, rheumatoid arthritis, systemic sclerosis, and Sjögren's syndrome are associated with increased cancer risk.
  • Mechanisms involve chronic inflammation, immune dysregulation, and loss of self-tolerance.
  • Cancer risk assessment should be integrated into the treatment of autoimmune diseases.

Conclusions:

  • Autoimmune diseases create a pro-tumorigenic environment.
  • Understanding the interplay between autoimmunity and cancer is vital for patient care.
  • Integrated management strategies are needed for patients with autoimmune diseases and cancer risk.