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Primary angiosarcoma of the breast: a case report
Soyoung Im1, Byung Joo Chae2, Sung Hun Kim3
1Department of Pathology, St. Vincent's Hospital, The Catholic University of Korea, College of Medicine Suwon, Republic of Korea.
International Journal of Clinical and Experimental Pathology
|January 15, 2020
Summary
Primary breast angiosarcoma is a rare cancer. This case report details a 39-year-old woman
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Primary breast angiosarcoma is an exceptionally rare malignancy, comprising less than 0.05% of all breast cancers.
- This report focuses on a unique case of primary angiosarcoma, offering comprehensive radiological and histological insights.
Observation:
- A 39-year-old woman presented with a diffuse, hard mass in her right breast.
- Ultrasonography identified a large, irregular, anechoic cystic mass replacing the entire breast.
- The patient had no prior history of radiation exposure.
Findings:
- Microscopic examination, immunohistochemical staining, and electron microscopy confirmed intermediate grade angiosarcoma.
- Postoperative chemoradiation therapy (adriamycin-ifosfamide and radiation) was administered.
- Multiple bone metastases developed nine months after surgery.
Implications:
- This case highlights the aggressive potential of intermediate grade primary breast angiosarcoma, even after multimodal treatment.
- Detailed radiological and histological documentation is crucial for understanding this rare tumor.
- Further research into effective therapeutic strategies for aggressive angiosarcoma is warranted.
