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Primary thyroid Burkitt lymphoma in a 15-year-old boy
Hong Wu1, Meng-Lan Huang1, Lu Liang2
1Department of Pathology, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
International Journal of Clinical and Experimental Pathology
|January 15, 2020
Summary
Primary thyroid Burkitt lymphoma (PTBL) is a rare pediatric cancer. This case report details a fatal PTBL in a 15-year-old boy, highlighting diagnostic features and treatment challenges.
Area of Science:
- Pediatric Oncology
- Hematology
- Pathology
Background:
- Primary thyroid Burkitt lymphoma (PTBL) is an exceptionally rare malignant tumor in children.
- Early diagnosis and treatment are crucial for managing aggressive pediatric cancers.
Observation:
- A 15-year-old boy presented with a rapidly enlarging neck mass and compressive symptoms.
- Imaging revealed a large, irregular thyroid mass and enlarged cervical lymph nodes.
- Pathologic examination confirmed Burkitt lymphoma with characteristic starry-sky phenomenon.
Findings:
- Immunohistochemistry showed a high proliferation rate (Ki67 ~100%) and positive C-MYC expression.
- The patient underwent thyroidectomy and CHOP chemotherapy.
- Despite treatment, the patient's condition deteriorated, leading to death.
Implications:
- This case underscores the aggressive nature of PTBL in pediatric patients.
- It highlights the importance of prompt diagnosis and multidisciplinary management for rare pediatric thyroid malignancies.
- Further research into effective therapeutic strategies for PTBL is warranted.
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