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Related Experiment Videos

Prostaglandin E2 suppositories as a second-trimester abortifacient.

R Rakhshani1, D A Grimes

  • 1Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, University of Southern California, Los Angeles 90033.

The Journal of Reproductive Medicine
|October 1, 1988
PubMed
Summary

Vaginal prostaglandin E2 suppositories effectively induce second-trimester abortions. This method is safe and simple, with a 90.4% abortion rate within 24 hours and minimal serious complications.

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Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Pharmacology

Background:

  • Second-trimester abortions are commonly performed via labor induction.
  • Optimal methods for inducing labor for abortion remain under investigation.

Purpose of the Study:

  • To evaluate the efficacy and safety of vaginal prostaglandin E2 suppositories for second-trimester abortion.

Main Methods:

  • Analysis of abortions performed between 14-24 menstrual weeks' gestation.
  • Utilized vaginal prostaglandin E2 suppositories for labor induction.

Main Results:

  • Achieved a 90.4% abortion rate within 24 hours.
  • Mean induction-to-abortion time was 13.8 hours.
  • Frequent gastrointestinal side effects, but infrequent hemorrhage, infection, and live births.
Keywords:
Abortifacient AgentsAbortion, Drug InducedAbortion, InducedBiologyEndocrine SystemFamily PlanningFertility Control, PostconceptionPhysiologyProstaglandinsVacuum Aspiration

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Conclusions:

  • Vaginal prostaglandin E2 suppositories offer a simple, effective, and safe method for second-trimester abortion.
  • This method requires minimal surgical skill.