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Association Between Unstable Angina and CXCL17: a New Potential Biomarker

Fu-Han Gong1, Xiao-Qiang Xiao1, Xue-Ping Zhang1

  • 1Department of Cardiology, Tongren Municipal People's Hospital, No.120 Taoyuan Avenue, Chuandong Education park, Bijiang District, Tongren City 554300, China.

Open Medicine (Warsaw, Poland)
|January 15, 2020
PubMed

Insights

Elevated serum CXCL17 levels are linked to unstable angina, suggesting this chemokine may serve as a novel biomarker for coronary heart disease instability and inflammation.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biochemistry

Background:

  • Chemokines play a role in atherosclerosis.
  • The specific role of chemokine CXCL17 in the development of atherosclerosis (atherogenesis) remains unclear.
  • Investigating CXCL17's involvement in coronary heart disease (CHD) is crucial.

Purpose of the Study:

  • To measure serum CXCL17 levels in patients with different stages of coronary heart disease (CHD).
  • To determine if CXCL17 levels correlate with atherosclerosis severity and inflammatory markers.
  • To explore CXCL17 as a potential biomarker for unstable angina (UA).

Main Methods:

  • Prospective study involving 48 unstable angina (UA) patients, 51 stable angina (SA) patients, and 41 controls (CG).
  • Coronary angiography for diagnosis and Gensini score for disease severity.
  • Enzyme-linked immunosorbent assay (ELISA) for CXCL17 levels; automated analyzer for lipid profiles and high-sensitivity C-reactive protein (hs-CRP).

Main Results:

  • Unstable angina (UA) patients exhibited significantly higher serum CXCL17 levels than stable angina (SA) patients and controls (CG).
  • Logistic regression identified CXCL17 as an independent risk factor for UA.
  • CXCL17 levels correlated positively with hs-CRP, indicating a link to inflammation, but not with the Gensini score.

Conclusions:

  • Elevated serum CXCL17 is associated with unstable angina (UA), suggesting a role in atherosclerotic plaque instability.
  • CXCL17 may serve as a potential new biomarker for identifying unstable angina (UA).
  • CXCL17's association with hs-CRP highlights its connection to inflammatory responses in cardiovascular disease.

Keywords:
CXCL17Gensini scoreLipid metabolism indicatorsangina pectoriscoronary angiographyhigh sensitivity C-reactive protein

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