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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
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While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
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Related Experiment Video

Updated: Dec 31, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Nightmares and the Cannabinoids.

Mortimer Mamelak1

  • 1Department of Psychiatry, University of Toronto, Baycrest Hospital, Permanent Address: 19 Tumbleweed Road, Toronto, Ontario M2J 2N2, Canada.

Current Neuropharmacology
|January 15, 2020
PubMed
Summary

Cannabinoids like Δ9 tetrahydrocannabinol can reduce post-traumatic nightmares. They may help mitigate trauma

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Traumatic events can lead to persistent nightmares and altered neurophysiological states.
  • Established post-traumatic adaptive changes can be resistant to reversal.

Purpose of the Study:

  • To examine the role of cannabinoids in mitigating post-traumatic stress disorder (PTSD) symptoms.
  • To explore the potential of cannabinoids in preventing long-term neurobiological alterations following trauma.

Main Methods:

  • Review of existing literature on cannabinoids, trauma, and PTSD.
  • Analysis of the mechanisms by which cannabinoids interfere with post-traumatic somatic adaptations.

Main Results:

  • Cannabinoids, including Δ9 tetrahydrocannabinol and nabilone, effectively reduce the intensity and frequency of post-traumatic nightmares.
Keywords:
Nightmarescannabinoidsepisodic memorypost-traumatic stress disordersharp wave ripple complexsleep

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  • Cannabinoids demonstrate the unique ability to interfere with adaptive neurophysiological, endocrine, and inflammatory changes post-trauma.

    • Conclusions:

    • Cannabinoids can suppress PTSD symptoms like nightmares but are not a definitive cure.
    • Early intervention with cannabinoids, potentially combined with other agents, may mitigate trauma-induced metabolic and nervous system changes.