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Updated: Dec 31, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
[Pathological and protective effects of tumor necrosis factor-alpha in multiple sclerosis]
I V Smagina1, S A Elchaninova2, A S Palashchenko1
1Altai State Medical University, Barnaul, Russia; Regional Clinical Hospital, Barnaul, Russia.
Abstract:
The immunomodulatory cytokine tumor necrosis factor-alpha (TNF-α) is involved in the regulation of both physiological and pathological processes in the central nervous system (CNS). The effects of TNF-α on CNS reported in clinical trials and experimental studies, evidence of involvement of this cytokine in the pathogenesis of multiple sclerosis are analyzed. Possible causes of failures of non-selective pharmacological inhibition of TNF-α effects in MS are considered in view of current concepts on mechanisms of TNF-α action.
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