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Multistimulus Responsive Biointerfaces with Switchable Bioadhesion and Surface Functions.

Yang Zhou1, Yanjun Zheng1, Ting Wei1

  • 1State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science , Soochow University , Suzhou , 215123 , P. R. China.

ACS Applied Materials & Interfaces
|January 15, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel multistimulus responsive biointerface that dynamically controls protein, bacterial, and cell adhesion. This smart surface responds to temperature, pH, and sugar, offering advanced biomedical applications.

Keywords:
bacterial attachmentcell attachmentdynamic covalent bondsmultistimulus responsive biointerfacesphenylboronic acidpoly(N-isopropylacrylamide)protein adsorption

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Biointerfacial Engineering

Background:

  • Stimuli-responsive biointerfaces are crucial for modulating biological interactions.
  • Biological environments are complex, necessitating surfaces with multi-stimulus responsiveness for switchable bioactivity.

Purpose of the Study:

  • To develop a multistimulus responsive biointerface with switchable bioadhesion and surface functions.
  • To enable control over protein adsorption, bacterial adhesion, and cell adhesion in response to temperature, pH, or sugar content.

Main Methods:

  • Fabrication of a silicon-based surface modified with a copolymer.
  • The copolymer incorporates a thermoresponsive component (poly(N-isopropylacrylamide)) and phenylboronic acid for pH and sugar responsiveness.
  • Dynamic boronate ester bonds were formed with diol-containing molecules to achieve responsiveness.

Main Results:

  • Demonstrated regulation of protein adsorption/release and bacterial/cell attachment/detachment by altering temperature, pH, and sugar content individually or simultaneously.
  • Achieved switchable surface functions, transitioning between killing and releasing bacteria via a diol-containing biocidal compound.
  • The multistimulus responsive surface exhibits enhanced adaptability to complex biological environments compared to single-stimulus surfaces.

Conclusions:

  • The developed multistimulus responsive biointerface offers precise control over biointeractions.
  • This adaptable surface is well-suited for complex biological settings.
  • Significant potential for diverse biomedical and biotechnology applications.