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PM2.5-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a

Jingyi Zhang1, Shuang Liang1, Ruihong Ning1

  • 1Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China.

Environment International
|January 15, 2020
PubMed

Insights

Fine particulate matter (PM2.5) exposure promotes atherosclerosis by disrupting lipid metabolism and increasing inflammation. These effects, including elevated vascular stiffness and aortic arch lesions, may persist even after a recovery period.

Area of Science:

  • Environmental Health
  • Cardiovascular Research
  • Metabolomics

Background:

  • Epidemiological studies link PM2.5 exposure to atherosclerosis and lipid dysregulation.
  • Specific lipid biomarkers involved in PM2.5-induced atherosclerosis remain largely unidentified.

Purpose of the Study:

  • To identify lipid biomarkers associated with atherosclerosis development following PM2.5 exposure.
  • To evaluate the pro-atherosclerotic effects of PM2.5 and its persistent impact during recovery.

Main Methods:

  • Targeted lipidomics to analyze lipid profiles.
  • Pulse wave Doppler ultrasound, oil red O, and H&E staining to assess vascular changes and lesions.
  • Mouse Inflammation Array to measure pro-inflammatory cytokines.

Main Results:

  • PM2.5 exposure increased vascular stiffness, aortic arch lesions, and pro-inflammatory cytokines.
  • Significant alterations in lipid metabolism were observed, including increased cholesterol esters and phospholipids, and decreased lysophospholipids and triglycerides.
  • These changes, particularly in glycerophospholipid and glycerolipid metabolism, showed a persistent impact post-recovery.

Conclusions:

  • PM2.5-induced inflammation and lipid dysregulation promote atherosclerotic lesion development.
  • The detrimental effects of PM2.5 on lipid metabolism and atherosclerosis may persist after a recovery period.
Keywords:
AtherosclerosisGlycerolipidsGlycerophospholipidsInflammationLipidomicPM(2.5)

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