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An outbreak of salmonellosis in newly imported cynomolgus monkeys
M Takasaka1, A Kohno, I Sakakibara
1Tsukuba Primate Center for Medical Science, National Institute of Health, Japan.
Abstract:
Serious salmonellosis occurred in groups of cynomolgus monkeys newly imported into Tsukuba Primate Center for Medical Science from the Philippines in 1985. During the quarantine period, Salmonella typhimurium (29 strains) and S. stanley (1 strain) were isolated from 30 of 130 imported monkeys. Twenty-eight of the 30 infected monkeys excreted mainly watery diarrhea, and occasionally bloody mucous stool. Seven of the 28 clinical cases infected with S. typhimurium resulted in death or in moribund state. In both the small and large intestines of autopsied monkeys, acute inflammatory changes were observed.
Insights
Newly imported cynomolgus monkeys experienced severe salmonellosis. Salmonella typhimurium caused significant illness and mortality, highlighting risks in primate imports.
Area of Science:
- Veterinary Medicine
- Primate Health
- Infectious Diseases
Background:
- Cynomolgus monkeys are vital models in biomedical research.
- Imported primates can introduce infectious diseases into research facilities.
- Salmonellosis poses a significant threat to non-human primate health and research integrity.
Purpose of the Study:
- To document an outbreak of salmonellosis in imported cynomolgus monkeys.
- To identify the causative agents and clinical manifestations of the disease.
- To assess the impact of Salmonella infection on the health of newly imported primates.
Main Methods:
- Isolation and identification of Salmonella strains from imported monkeys.
- Clinical observation of infected animals, including monitoring stool consistency and general condition.
- Necropsy and histopathological examination of affected tissues in deceased or moribund monkeys.
Main Results:
- Salmonella typhimurium and Salmonella stanley were isolated from 30 of 130 imported cynomolgus monkeys.
- The majority of infected monkeys exhibited diarrhea, with some cases progressing to bloody mucous stool.
- Seven out of 28 clinically affected monkeys died or were in a moribund state, with observed acute inflammatory changes in the intestines.
Conclusions:
- Imported cynomolgus monkeys are susceptible to serious salmonellosis.
- Salmonella typhimurium infection can lead to severe clinical signs, including mortality, in these animals.
- Strict quarantine and health monitoring protocols are crucial for imported primates to prevent disease outbreaks.