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Rationally Designed Ruthenium Complexes for Breast Cancer Therapy
Golara Golbaghi1, Annie Castonguay1
1Organometallic Chemistry Laboratory for the Design of Catalysts and Therapeutics, INRS-Centre Armand-Frappier Santé Biotechnologie, Université du Québec, Laval, QC H7V 1B7, Canada.
Ruthenium complexes show promise for treating breast cancer, particularly hormone receptor-positive and triple-negative types. This review highlights rationally designed ruthenium compounds with bioactive ligands for enhanced anticancer drug development.
Area of Science:
- Medicinal Chemistry
- Oncology
- Inorganic Chemistry
Background:
- Breast cancer is a leading cause of cancer death in women globally.
- Ruthenium-based complexes are emerging as promising anticancer agents.
- Bioactive ligands enhance the multitargeting potential of ruthenium complexes.
Purpose of the Study:
- To review rationally designed ruthenium complexes for hormone receptor-positive (ER+/PR+) breast cancer.
- To highlight successful ruthenium complexes for triple-negative breast cancer (TNBC).
Main Methods:
- Literature review of ruthenium complexes targeting breast cancer.
- Focus on complexes with carefully selected bioactive ligands.
- Inclusion of examples for both ER+/PR+ and TNBC.
Main Results:
- Several ruthenium complexes with bioactive ligands show potential for ER+/PR+ breast cancer.
- Notable ruthenium complexes have demonstrated efficacy against TNBC.
- Ligand design is crucial for multitargeting and broader action.
Conclusions:
- Ruthenium complexes offer a promising avenue for novel breast cancer therapeutics.
- Targeted ligand design can improve efficacy against specific breast cancer subtypes.
- Further research into ruthenium-based drugs could lead to improved patient outcomes.
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