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STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons

Joanna Gruszczynska-Biegala1,2, Klaudia Strucinska1, Filip Maciag1

  • 1Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, 02-109 Warsaw, Poland.

Cells
|January 16, 2020
PubMed
Summary

Neuronal Store-Operated Calcium Entry (nSOCE) is modulated by NMDA receptors. STIM proteins interact with NMDA receptor subunits, influencing calcium levels and offering therapeutic targets for neurological disorders.

Keywords:
Ca2+ homeostasisNMDA receptorSTIM proteinsendoplasmic reticulum (ER)neuronal store-operated calcium entry (nSOCE)neuronsorganellar Ca2+plasma membrane (PM)

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