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Related Experiment Video

Updated: Dec 30, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Circular RNAs in the tumour microenvironment.

Zhonghua Ma^1,2, You Shuai³, Xiangyu Gao^1,2

¹Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China.

Molecular Cancer

|January 16, 2020

Summary

Circular RNAs (circRNAs) are key regulators in tumors, influencing the tumor microenvironment (TME). Understanding circRNAs offers new biomarkers and therapeutic strategies for cancer treatment and drug resistance.

Keywords:

Biomarker Circular RNAs Drug resistance Molecular mechanism Target Tumour microenvironment

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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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Published on: October 21, 2022

Identification of Circular RNAs using RNA Sequencing

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Published on: November 14, 2019

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Published on: August 28, 2018

Area of Science:

Molecular Biology
Cancer Research
RNA Biology

Background:

Circular RNAs (circRNAs) are novel endogenous non-coding RNAs prevalent in eukaryotes.
circRNAs play critical roles in regulating various tumors and the tumor microenvironment (TME).

Purpose of the Study:

To provide a systematic overview of circRNAs' interplay with TME components.
To highlight circRNAs as potential biomarkers and therapeutic targets in cancer.
To discuss circRNAs' role in driving drug resistance in tumors.

Main Methods:

Review of existing literature on circRNA biogenesis, characteristics, and classification.
Analysis of mechanistic models of circRNAs.
Systematic overview of circRNA interactions within the TME.

Main Results:

circRNAs modulate tumorigenesis, angiogenesis, immune response, and metastasis by reprogramming TME components.
circRNAs are involved in the development of drug resistance in tumors.
circRNAs represent promising targets for cancer therapy.

Conclusions:

Understanding circRNAs' role in the TME is crucial for developing novel cancer biomarkers and therapies.
Targeting circRNAs and TME components may enhance therapeutic efficiency for cancer treatment.