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Related Concept Videos

Anatomy of the Genitourinary System II: Bladder and Urethra01:19

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The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
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Related Experiment Video

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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Methods for Assessing Lower Urinary Tract Function in Animal Models.

Andrea M Sartori1, Thomas M Kessler2, Martin E Schwab3

  • 1Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland; Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

European Urology Focus
|January 16, 2020
PubMed
Summary
This summary is machine-generated.

Understanding bladder control requires advanced diagnostics. Urodynamics testing provides objective evaluation for diagnosing lower urinary tract dysfunction, aiding in developing new urology treatments.

Keywords:
Animal modelsMetabolic cageNeuro-urologyUrodynamicsVoid-spot assay

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Area of Science:

  • Urology
  • Animal Models
  • Physiology

Background:

  • Lower urinary tract dysfunction impacts many patients, with limited therapeutic options.
  • The mechanisms underlying bladder control failure are poorly understood, necessitating further basic research.
  • Novel treatment strategies in urology require elucidation of pathological mechanisms.

Purpose of the Study:

  • To summarize current methods for assessing lower urinary tract function in animal models.
  • To highlight the importance of diagnostic accuracy in understanding bladder dysfunction.
  • To emphasize the role of research in improving human health through urological advancements.

Main Methods:

  • Noninvasive assays like the void-spot assay and metabolic cage.
  • Invasive urodynamics investigations for objective evaluation.
  • Utilizing rodent models for preclinical assessment of bladder function.

Main Results:

  • Noninvasive tests offer preliminary insights into system functionality.
  • Urodynamics testing provides objective data for distinguishing pathologies.
  • Urodynamics enables detailed investigation of neuronal malfunctions in bladder control.

Conclusions:

  • Accurate diagnosis of bladder dysfunction is crucial for effective treatment.
  • Urodynamics assessments are essential for a detailed and objective evaluation.
  • Research into bladder control mechanisms using various methods can improve human health outcomes.