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Related Experiment Videos

Gluten-sensitive enteropathy in a cynomolgus monkey.

J D Wagner1, C P Jerome, M R Adams

  • 1Department of Comparative Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.

Laboratory Animal Science
|October 1, 1988
PubMed
Summary
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A cynomolgus macaque experienced malabsorption syndrome, presenting with weight loss and diarrhea. Dietary changes removing grain products resolved the condition, suggesting a gluten-sensitivity enteropathy-like syndrome.

Area of Science:

  • Veterinary Medicine
  • Gastroenterology
  • Primate Research

Background:

  • Malabsorption syndromes can significantly impact animal health and research outcomes.
  • Cynomolgus macaques are important models in biomedical research.

Observation:

  • A cynomolgus macaque exhibited clinical signs of malabsorption, including weight loss, diarrhea, and poor nutrient absorption.
  • Pathological examination revealed villous atrophy and inflammation in the small intestine.

Findings:

  • The macaque presented with hypoalbuminemia, steatorrhea, and diminished D-xylose absorption.
  • Histopathology showed total villous atrophy, crypt hyperplasia, and a plasmacytic-lymphocytic infiltrate.

Implications:

  • Dietary modification, specifically removing grain products, led to complete clinical and pathological recovery.

Related Experiment Videos

  • This suggests a potential gluten-sensitivity enteropathy-like condition in non-human primates.
  • Highlights the importance of diet in primate gastrointestinal health and research models.