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An experimental hyperlipidemia model with periodontitis in mice
Xiaoxuan Liu1, Zhiguo Wang2, Qiuxia Ji1
1Department of Stomatology, The Affiliated Hospital of Qingdao University, College of Stomatology, Qingdao University Qingdao 266003, Shandong, China.
International Journal of Clinical and Experimental Pathology
|January 16, 2020
Summary
This study successfully established a mouse model of hyperlipidemia and periodontitis using Apolipoprotein E-deficient mice and ligation. This model demonstrated increased alveolar bone loss and inflammatory markers, indicating a link between these conditions.
Area of Science:
- Oral biology
- Cardiovascular research
- Immunology
Background:
- Periodontitis and hyperlipidemia share a bidirectional relationship.
- Existing animal models may not fully capture this complex interaction.
Purpose of the Study:
- To introduce and validate an experimental model of hyperlipidemia with periodontitis in mice.
- To investigate the impact of hyperlipidemia on periodontitis progression.
Main Methods:
- Apolipoprotein E-deficient (ApoE-/-) mice were fed a high-fat diet (HFD) and subjected to maxillary tooth ligation.
- Serum lipid profiles, inflammatory cytokines (IL-6, IL-10, TNF-α), alveolar bone loss (ABL), and atherosclerotic lesions were assessed.
Main Results:
- ApoE-/- mice on HFD with ligation showed significantly increased serum lipids, IL-6, IL-10, and TNF-α levels compared to controls.
- Greater ABL and observable atherosclerotic lesions were noted in the experimental group.
- The model effectively induced both hyperlipidemia and periodontitis.
Conclusions:
- An economical and time-efficient mouse model for studying hyperlipidemia and periodontitis was successfully established.
- This model in ApoE-/- mice provides a valuable platform for further research into the interlinked pathogenesis of these conditions.
- The findings support the clinical observation of a bidirectional link between periodontitis and hyperlipidemia.
