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Related Concept Videos

Primary Lymphoid Organs01:16

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Updated: Dec 30, 2025

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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EBV-positive lymphoproliferative disease: a case report.

Haojie Du1, Hongtan Chen1, Panpan Ma2

  • 1Department of Gastroenterology, First Affiliated Hospital of Zhejiang University School of Medicine #79 Qingchun Road, Hangzhou, Zhejiang Province, China.

International Journal of Clinical and Experimental Pathology
|January 16, 2020
PubMed
Summary

This case highlights a rare instance of Epstein-Barr virus (EBV)-positive lymphoproliferative disease (EBV+LPD) presenting with gastrointestinal symptoms. Early consideration of rare conditions is crucial when conventional treatments fail.

Keywords:
EBV-positive lymphoproliferative diseaseinflammatory bowel diseaseintestinal tuberculosis

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Area of Science:

  • Gastroenterology
  • Oncology
  • Infectious Diseases

Background:

  • Bloody stool and fever are often initially attributed to inflammatory bowel disease or intestinal tuberculosis.
  • Epstein-Barr virus (EBV) infection is common, but EBV-positive lymphoproliferative disease (EBV+LPD) affecting the gut is rare and often overlooked.

Purpose of the Study:

  • To report a rare case of EBV+LPD presenting with severe gastrointestinal symptoms and skin manifestations.
  • To emphasize the importance of considering rare diagnoses in patients with refractory gastrointestinal issues.

Main Methods:

  • Clinical presentation of a 34-year-old female with prolonged bloody stools, fever, and skin lesions.
  • Diagnostic procedures including colonoscopy, anti-tuberculosis therapy trial, repeat colonoscopy, serum EBV testing (IgM, IgG, DNA), and skin biopsy.
  • Histopathological examination and immunohistochemistry to identify Epstein-Barr virus infection and T-lymphocyte abnormalities.

Main Results:

  • Initial treatments for suspected intestinal tuberculosis and inflammatory bowel disease were ineffective.
  • Diagnostic tests confirmed EBV infection and EBV-positive T-lymphocyte proliferative disease (EBV+T-LPD), specifically hydroa vacciniforme-like lymphoma.
  • The patient presented with multiple ulcers in the small intestine and colon consistent with EBV+LPD.

Conclusions:

  • This case underscores the necessity of considering rare conditions like EBV+LPD in patients with persistent gastrointestinal symptoms unresponsive to standard therapies.
  • Timely diagnosis and definitive treatment are critical for managing EBV+LPD involving the gastrointestinal tract and skin.